IP6

WHAT IT DOES

IP6 (myo-inositol 1,2,3,4,5,6-hexakisphosphate) has six phosphate groups that chelate metal ions: (1) Iron chelation — IP6 binds free Fe²⁺/Fe³⁺, preventing the Fenton reaction (Fe²⁺ + H₂O₂ → Fe³⁺ + OH• + OH⁻), which generates the most damaging reactive oxygen species. Excess free iron promotes cancer growth and oxidative DNA damage; (2) IP6 dephosphorylation in cells — IP6 is dephosphorylated to IP5, IP4, IP3 (second messengers) that activate cell cycle checkpoints → G1 arrest and apoptosis in cancer cells; (3) NK cell activation — mechanism unclear but may involve IP3/IP4 signaling in lymphocytes; (4) Calcium chelation — reduces urinary calcium saturation (kidney stone prevention). The KEY: taken with food, chelation blocks dietary mineral absorption (anti-nutrient). Taken between meals, chelation targets free iron and excess minerals (therapeutic).

OPTIMAL DOSAGE

SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)