Is Calcium D-Glucarate safe to take daily?

Calcium D-Glucarate is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Calcium D-Glucarate

MODERATE EVIDENCEMineralLast updated

AVELOR SUMMARY

Calcium D-glucarate supports Phase II liver detoxification by inhibiting beta-glucuronidase — the enzyme that REVERSES glucuronidation (the body's way of tagging toxins/hormones for excretion). By blocking beta-glucuronidase, D-glucarate prevents recycling of estrogen and toxins back into circulation. Used for estrogen metabolism support and 'detoxification.' Memorial Sloan Kettering lists it as a studied compound for cancer prevention. Dose: 200-500mg/day. Found naturally in oranges, apples, broccoli. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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