What is the recommended dose of Boron?

- **General support:** 3-6mg/day - **Bone health:** 3-6mg/day (combined with calcium, D, and magnesium) - **Testosterone support:** 6-10mg/day - **Upper tolerable limit:** 20mg/day (adults)

Is Boron safe to take daily?

Boron is rated "Use Caution" based on clinical evidence. - No adverse effects at doses ≤20mg/day - Toxicity (nausea, vomiting, diarrhea) at >20mg/day - Severe toxicity at gram-level doses (not achievable through supplementation)

Does Boron interact with any medications?

Boron has 1 known drug interaction, including interactions with Estrogen therapy / HRT. Check with your doctor before combining with prescription medications.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Boron

MODERATE EVIDENCEMineralLast updated April 2026

AVELOR SUMMARY

Boron is an ultra-trace mineral with emerging evidence for bone health, testosterone support, and cognitive function. Our research shows it influences calcium, magnesium, and vitamin D metabolism, and may modestly increase free testosterone by reducing SHBG — but the evidence base is thin and mostly observational. It's cheap, safe at low doses, and likely beneficial for people with inadequate dietary intake.

EVIDENCE GRADES

Bone mineral density (postmenopausal women)Moderate — observational + interventional

B-

Testosterone (free testosterone via SHBG reduction)Limited — small studies (PMID: 21129941)

C+

Cognitive functionDeprivation studies show impairment; supplementation data weak

Arthritis / joint healthEpidemiological associations + limited trials

Vitamin D metabolismMay increase 25(OH)D levels when boron-depleted

C+

WHAT IT DOES

Boron influences the metabolism of calcium, magnesium, phosphorus, and vitamin D. It inhibits the hydroxylase enzymes that deactivate 17β-estradiol and vitamin D, effectively extending their half-lives. Boron also reduces SHBG (sex hormone-binding globulin), which increases free testosterone — though the magnitude is modest.

Dietary boron comes from fruits, vegetables, nuts, and legumes. Average dietary intake is 1-3mg/day. The proposed adequate intake is 1-13mg/day depending on the source.

OPTIMAL DOSAGE

General support: 3-6mg/day
Bone health: 3-6mg/day (combined with calcium, D, and magnesium)
Testosterone support: 6-10mg/day
Upper tolerable limit: 20mg/day (adults)

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DRUG INTERACTIONS

Estrogen therapy / HRTModerate

Boron may increase estradiol levels; additive estrogenic effects

SAFETY PROFILE

Drug Interactions

Side Effects

No adverse effects at doses ≤20mg/day
Toxicity (nausea, vomiting, diarrhea) at >20mg/day
Severe toxicity at gram-level doses (not achievable through supplementation)

Pregnancy & Lactation

No safety data for supplemental boron during pregnancy. Dietary boron from foods is safe.

WADA Status

Not Prohibited

HOW AVELOR SCORES THIS

3-6mg in a multivitamin or bone health formula: score normally

>10mg standalone: note that evidence is thin at higher doses

Estrogen/HRT users: flag additive estrogenic effect

Often underdosed or absent in multivitamins — Dose AI can flag this as a gap in bone health formulas

CLINICAL REFERENCES

Naghii MR et al. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines.

PMID: 21129941

Nielsen FH. Studies on the relationship between boron and magnesium.

PMID: 8112856

Penland JG. Dietary boron, brain function, and cognitive performance.

PMID: 7889887

RELATED RESEARCH

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

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