and methyl-folate.md. Two forms: folic acid (synthetic, must be converted by MTHFR) and methylfolate/5-MTHF (active, bypasses MTHFR). 40% of population has MTHFR C677T variant with reduced conversion. Neural tube defect prevention: 400-800μg/day pre-conception. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.