What is the recommended dose of Tribulus Terrestris?

- **Typical study dose:** 250-1,500mg/day - **Standardized to furostanol saponins or protodioscin:** 200-450mg/day - Despite dosing, testosterone remains unaffected in clinical trials

Is Tribulus Terrestris safe to take daily?

Tribulus Terrestris is rated "Use Caution" based on clinical evidence. - GI upset (most common) - Insomnia, restlessness - Case reports of hepatotoxicity and nephrotoxicity (rare, high-dose)

Does Tribulus Terrestris interact with any medications?

Tribulus Terrestris has 3 known drug interactions, including interactions with Antihypertensives, Diabetes medications, Lithium. Check with your doctor before combining with prescription medications.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Tribulus Terrestris

LIMITED EVIDENCEBotanicalLast updated April 2026

AVELOR SUMMARY

Tribulus terrestris is one of the most marketed "testosterone boosters" — and one of the most thoroughly debunked. Our research shows multiple well-designed trials found NO effect on testosterone, LH, or FSH in healthy men. The only populations that may benefit are those with specific sexual dysfunction or very low baseline libido. If you're buying tribulus for testosterone, you're wasting money.

EVIDENCE GRADES

Testosterone increaseDefinitively negative in multiple trials (PMID: 17530942)

Libido / sexual functionSome positive signals, likely non-hormonal mechanism

C+

Exercise performanceNo evidence of benefit

Erectile dysfunctionLimited positive data; not testosterone-mediated

Blood sugar reductionPreliminary — some positive trials in diabetic models

OPTIMAL DOSAGE

Typical study dose: 250-1,500mg/day
Standardized to furostanol saponins or protodioscin: 200-450mg/day
Despite dosing, testosterone remains unaffected in clinical trials

Scan a supplement containing Tribulus Terrestris

DRUG INTERACTIONS

AntihypertensivesMinor

May have mild diuretic/BP effects

Diabetes medicationsModerate

Animal data shows glucose-lowering; monitor in diabetics

LithiumModerate

Diuretic properties may increase lithium levels

SAFETY PROFILE

Drug Interactions

Side Effects

GI upset (most common)
Insomnia, restlessness
Case reports of hepatotoxicity and nephrotoxicity (rare, high-dose)

Pregnancy & Lactation

AVOID — insufficient safety data; potential hormonal effects in animal models

WADA Status

Not Prohibited

HOW AVELOR SCORES THIS

Auto-flag for ANY testosterone claim: "Multiple clinical trials found no effect on testosterone in healthy men"

Products in "testosterone booster" blends: flag primary ingredient ineffectiveness

Libido claims: slightly more supportable but mechanism is NOT testosterone-related

Score penalty for testosterone marketing without evidence

One of the supplements where Dose AI's evidence-based approach provides most consumer value

CLINICAL REFERENCES

Neychev VK, Mitev VI. The aphrodisiac herb Tribulus terrestris does not influence androgen production in young men.

PMID: 17530942

Qureshi A et al. A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and pro-erectile activity.

PMID: 24630840

Rogerson S et al. The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during resistance training.

PMID: 17530942

RELATED RESEARCH

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Scan Your Tribulus Terrestris Supplement Browse all ingredients

Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 834 Ingredients Browse All 20 Conditions

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Tribulus Terrestris

LIMITED EVIDENCEBotanicalLast updated April 2026

AVELOR SUMMARY

EVIDENCE GRADES

Testosterone increaseDefinitively negative in multiple trials (PMID: 17530942)

Libido / sexual functionSome positive signals, likely non-hormonal mechanism

C+

Exercise performanceNo evidence of benefit

Erectile dysfunctionLimited positive data; not testosterone-mediated

Blood sugar reductionPreliminary — some positive trials in diabetic models

OPTIMAL DOSAGE

Typical study dose: 250-1,500mg/day
Standardized to furostanol saponins or protodioscin: 200-450mg/day
Despite dosing, testosterone remains unaffected in clinical trials

Scan a supplement containing Tribulus Terrestris

DRUG INTERACTIONS

AntihypertensivesMinor

May have mild diuretic/BP effects

Diabetes medicationsModerate

Animal data shows glucose-lowering; monitor in diabetics

LithiumModerate

Diuretic properties may increase lithium levels

SAFETY PROFILE

Drug Interactions

Side Effects

GI upset (most common)
Insomnia, restlessness
Case reports of hepatotoxicity and nephrotoxicity (rare, high-dose)

Pregnancy & Lactation

AVOID — insufficient safety data; potential hormonal effects in animal models

WADA Status

Not Prohibited

HOW AVELOR SCORES THIS

Auto-flag for ANY testosterone claim: "Multiple clinical trials found no effect on testosterone in healthy men"

Products in "testosterone booster" blends: flag primary ingredient ineffectiveness

Libido claims: slightly more supportable but mechanism is NOT testosterone-related

Score penalty for testosterone marketing without evidence

One of the supplements where Dose AI's evidence-based approach provides most consumer value

CLINICAL REFERENCES

Neychev VK, Mitev VI. The aphrodisiac herb Tribulus terrestris does not influence androgen production in young men.

PMID: 17530942

Qureshi A et al. A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and pro-erectile activity.

PMID: 24630840

Rogerson S et al. The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during resistance training.

PMID: 17530942

RELATED RESEARCH

Apigenin

ApigeninChamomile extract

Apocynum Venetum

ArjunaArjuna bark

Scan Your Tribulus Terrestris Supplement Browse all ingredients

Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 834 Ingredients Browse All 20 Conditions