What is the recommended dose of Apigenin?

- **Look for:** "Apigenin 50mg" as isolated compound, or chamomile extract standardized to 1.2% apigenin - **Avoid:** Unstandardized chamomile powder (apigenin content unpredictable); proprietary "...

Is Apigenin safe to take daily?

Apigenin is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Apigenin

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

Apigenin is a flavonoid found in chamomile, parsley, and celery that acts as a positive allosteric modulator of GABA-A receptors — producing anxiolytic and sleep-promoting effects without the addiction risk of benzodiazepines. Andrew Huberman's popularization of 50mg apigenin for sleep drove massive consumer interest, though our research shows the clinical evidence base is thinner than the hype. The strongest data comes from chamomile extract trials (standardized to apigenin), where anxiety reduction reached 50% in one 8-week RCT.

WHAT IT DOES

Apigenin binds to the benzodiazepine site on GABA-A receptors, but as a partial agonist rather than the full agonist that drugs like Xanax are. This means it calms without the heavy sedation, memory impairment, or addiction potential. It also inhibits CD38 — an enzyme that degrades NAD+ — which is why it appears in longevity stacks alongside NMN or NR. The dual GABA + NAD+ mechanism makes it uniquely positioned at the intersection of sleep and aging science.

OPTIMAL DOSAGE

Look for: "Apigenin 50mg" as isolated compound, or chamomile extract standardized to 1.2% apigenin
Avoid: Unstandardized chamomile powder (apigenin content unpredictable); proprietary "sleep blends" with undisclosed apigenin amount
Minimum effective dose: 50mg isolated apigenin for sleep; 220mg standardized chamomile for anxiety
Third-party tested brands: Swanson (isolated apigenin), NOW Foods (chamomile extract)

Scan a supplement containing Apigenin

SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

RELATED RESEARCH

Scan Your Apigenin Supplement Browse all ingredients

Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Apigenin

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

WHAT IT DOES

OPTIMAL DOSAGE

Look for: "Apigenin 50mg" as isolated compound, or chamomile extract standardized to 1.2% apigenin
Avoid: Unstandardized chamomile powder (apigenin content unpredictable); proprietary "sleep blends" with undisclosed apigenin amount
Minimum effective dose: 50mg isolated apigenin for sleep; 220mg standardized chamomile for anxiety
Third-party tested brands: Swanson (isolated apigenin), NOW Foods (chamomile extract)

Scan a supplement containing Apigenin

SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

RELATED RESEARCH

Scan Your Apigenin Supplement Browse all ingredients

Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 834 Ingredients Browse All 20 Conditions