Is Pycnogenol® safe to take daily?

Pycnogenol® is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Pycnogenol®

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

Pycnogenol® is covered in our Pine Bark Extract monograph. See `pine-bark-extract.md` for full details. This file exists as a cross-reference — Pycnogenol® IS French maritime pine bark extract (standardized from Pinus pinaster). With 160+ clinical trials, it's the most studied branded botanical extract. Key applications: blood pressure, ADHD in children, skin anti-aging, endometriosis, and erectile dysfunction. See: `pine-bark-extract.md` --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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