Essential fatty acids with strong evidence for cardiovascular health and inflammation reduction. EPA and DHA are the bioactive forms, with distinct benefits for heart health and brain function respectively.
Reduces triglycerides
STRONGDecreases hepatic VLDL synthesis and increases fatty acid beta-oxidation
Reduces systemic inflammation
STRONGEPA and DHA are precursors to anti-inflammatory resolvins and protectins
Supports brain health and cognition
MODERATEDHA is a structural component of neuronal membranes; maintains membrane fluidity
May reduce depressive symptoms
MODERATEEPA modulates neuroinflammation and serotonin signaling
COMMON: 1000-2000 mg EPA+DHA
TIMING: With a meal containing fat for absorption
Combined EPA+DHA dose, not total fish oil. For depression, higher EPA:DHA ratios (>60% EPA) show better results. Triglyceride form is better absorbed than ethyl ester.
Safety
Dangerous interactions. Talk to your prescriber before using this supplement if you take any of these.
Warfarin (Coumadin)
Omega-3 inhibits platelet aggregation, producing an additive anticoagulant effect on top of warfarin.
Source: PMID: 25062404
Clopidogrel (Plavix)
Dual antiplatelet effect.
Source: FDA label
High-dose Aspirin
Additive antiplatelet effect.
Source: Clinical consensus
Moderate interactions. Monitoring, timing separation, or dose adjustment may be required.
Blood pressure medications
Omega-3 may lower BP modestly.
Source: Clinical consensus
Orlistat (Alli)
Reduces fat absorption, including omega-3.
Source: FDA label
Stop 2 weeks before surgery
Bleeding risk from antiplatelet effect.
Educational information only. This is not medical advice. These statements have not been evaluated by the FDA. Talk to your prescriber before starting, stopping, or combining any supplement with prescription medication.