Beta-hydroxy beta-methylbutyrate — leucine metabolite. 3g/day reduces muscle protein breakdown during caloric deficit, illness, or injury. Most useful for PREVENTING catabolism (elderly, hospital, cutting), NOT for building muscle in healthy trained individuals. The Wilson 2014 study showing 7.4kg lean mass gain was never replicated and widely criticized. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.