What is the recommended dose of Gotu Kola?

- **Look for:** TTFCA standardized extract (40% asiaticoside); ECa 233 extract; 60-180mg triterpene fraction; or 500-1,000mg crude extract - **Avoid:** "Gotu kola" with no triterpene standardizatio...

Is Gotu Kola safe to take daily?

Gotu Kola is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Gotu Kola

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

Gotu kola is a traditional Ayurvedic and Chinese medicine herb with two distinct clinical applications: (1) wound healing and scar reduction (the triterpenes madecassoside and asiaticoside stimulate collagen synthesis by 200-300%), and (2) anxiety and cognitive enhancement. Our research shows it's one of the rare herbs where the dermatological evidence is STRONGER than the nootropic evidence — the wound healing mechanism is well-characterized at the molecular level (SMAD pathway activation). A 2010 study found it reduced anxiety by 30% after a single dose, but the cognitive data is mostly from animal studies.

WHAT IT DOES

The triterpenes (asiaticoside, madecassoside, asiatic acid, madecassic acid) have two distinct pharmacological actions: (1) For wound healing/collagen: they activate the TGF-β/SMAD signaling pathway in fibroblasts, dramatically increasing type I and type III collagen synthesis, fibronectin, and glycosaminoglycan production. They also increase tensile strength of new skin by improving collagen cross-linking. (2) For anxiety/cognition: they modulate GABAergic neurotransmission and reduce corticosterone (stress hormone), though the exact CNS mechanism is less well-characterized than the dermatological pathway.

OPTIMAL DOSAGE

Look for: TTFCA standardized extract (40% asiaticoside); ECa 233 extract; 60-180mg triterpene fraction; or 500-1,000mg crude extract
Avoid: "Gotu kola" with no triterpene standardization; confusing with cola nut (different plant entirely — contains caffeine)
Minimum effective dose: 60mg TTFCA; or 500mg crude extract
Third-party tested brands: NOW Foods, Nature's Way, Gaia Herbs

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

No critical interactions identified.

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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