Gamma-tocopherol is the PREDOMINANT vitamin E form in the American diet (70% from soybean oil) but supplements typically contain only alpha-tocopherol. Gamma-T has unique anti-inflammatory activity: it traps reactive nitrogen species (peroxynitrite) that alpha-T cannot. A 2002 study found gamma-T reduced markers of inflammation (PGE2) by 50% while alpha-T alone had no effect. High-dose alpha-T supplementation DEPLETES gamma-T (competitive displacement). This may explain why the SELECT trial found alpha-T supplementation increased prostate cancer — it depleted protective gamma-T. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.