Is Ergothioneine safe to take daily?

Ergothioneine is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Ergothioneine

MODERATE EVIDENCEAmino AcidLast updated

AVELOR SUMMARY

Ergothioneine is a unique amino acid produced exclusively by fungi and soil bacteria — humans have a specific transporter for it (OCTN1/SLC22A4), suggesting evolutionary importance. It accumulates in mitochondria as a potent antioxidant. Found in mushrooms (esp. oyster, king oyster, shiitake), tempeh, and organ meats. Blood levels decline with age and correlate with cognitive decline. The 'longevity vitamin' hypothesis (Ames 2018): ERGO may be conditionally essential. MitoPrime® is a branded supplement form. Dose: 5-25mg/day. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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BCAAs / EAAs

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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