Ergothioneine is a unique amino acid produced exclusively by fungi and soil bacteria — humans have a specific transporter for it (OCTN1/SLC22A4), suggesting evolutionary importance. It accumulates in mitochondria as a potent antioxidant. Found in mushrooms (esp. oyster, king oyster, shiitake), tempeh, and organ meats. Blood levels decline with age and correlate with cognitive decline. The 'longevity vitamin' hypothesis (Ames 2018): ERGO may be conditionally essential. MitoPrime® is a branded supplement form. Dose: 5-25mg/day. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.