Is Cissus Quadrangularis safe to take daily?

Cissus Quadrangularis is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Cissus Quadrangularis

MODERATE EVIDENCEBotanicalLast updated

AVELOR SUMMARY

Ayurvedic 'bone setter' herb with evidence for: (1) bone healing acceleration — reduced fracture healing time by 33% in a 1976 Indian study; (2) weight loss — 800mg/day CQR-300® extract reduced body weight, waist circumference, and fasting blood sugar in a 2006 RCT; (3) joint pain — reduced WOMAC scores in knee OA. Contains ketosteroids (anabolic) and ascorbic acid. The bone-healing evidence is old but mechanistically supported (osteoblast stimulation). Dose: 300-1,200mg/day. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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