Yohimbine is an alpha-2 adrenergic antagonist derived from the bark of the Pausinystalia yohimbe tree. Our research shows it's the only supplement with direct mechanistic evidence for stubborn fat mobilization — it blocks the alpha-2 receptors that prevent lipolysis in problem areas (lower abdomen, thighs). However, it's also one of the most dangerous supplements available: it reliably increases heart rate, blood pressure, and anxiety, and has caused documented cases of cardiac arrhythmias and hypertensive crises.
Additive sympathomimetic effects → hypertension, tachycardia, arrhythmia
Directly opposes antihypertensive effect (yohimbine RAISES BP)
Additive noradrenergic effects; may worsen anxiety/panic
Hypertensive crisis risk — CONTRAINDICATED
Additive cardiovascular effects
Directly opposes clonidine's alpha-2 agonism
May enhance yohimbine's anxiogenic effects
Yohimbine bark extract (sold as "yohimbe") varies WILDLY in actual yohimbine content — testing found 0-12mg per capsule regardless of label claim (PMID: 26344461). Only pharmaceutical-grade yohimbine HCl allows reliable dosing. Yohimbe bark extract is essentially uncontrollable.
Not Prohibited (but stimulant monitoring threshold applies)
Ostojic SM. Yohimbine: the effects on body composition and exercise performance in soccer players.
Cohen PA et al. Yohimbe supplement labeling: How accurate is it? A study of yohimbe supplements.
Charney DS et al. Yohimbine and human anxiety research.
Riley AJ. Yohimbine in the treatment of erectile disorder.
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated: April 2026
Not medical advice. Based on published clinical research and systematic reviews.