Yerba mate contains: (1) caffeine (1-1.5% by weight) — adenosine receptor antagonism, catecholamine release, thermogenesis; (2) theobromine — mild bronchodilator and mood elevator (same compound as in chocolate); (3) chlorogenic acids — inhibit hepatic glucose-6-phosphatase (reduce glucose output) and intestinal α-glucosidase (slow sugar absorption); (4) saponins (matesaponins) — inhibit pancreatic lipase (reduce fat absorption) and have anti-inflammatory/antimicrobial activity; (5) polyphenols — antioxidant and NF-κB inhibition. The fat oxidation enhancement during exercise is likely synergistic between caffeine (catecholamine-driven lipolysis) and chlorogenic acid (fatty acid oxidation enhancement).
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.