TUDCA is a bile acid with potent hepatoprotective, neuroprotective, and endoplasmic reticulum stress-reducing properties. Our research shows strong evidence for cholestatic liver disease and growing evidence for general liver protection, including steroid-users and high-dose supplement consumers. It's become the go-to liver support supplement in the bodybuilding community for good reason — the mechanism is legitimate.
Directly binds TUDCA, reducing absorption and efficacy
May reduce TUDCA absorption
TUDCA may alter cyclosporine absorption and enterohepatic cycling
Not Prohibited
Beuers U. Drug insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis.
Ozcan U et al. Chemical chaperones reduce ER stress and restore glucose homeostasis.
Elia AE et al. Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis.
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated: April 2026
Not medical advice. Based on published clinical research and systematic reviews.