What is the recommended dose of Sulforaphane?

- **Look for:** Broccoli sprout extract WITH active myrosinase enzyme; or stabilized sulforaphane with quantified sulforaphane content (mg); Prostaphane, Avmacol, or BroccoMax brands - **Avoid:** P...

Is Sulforaphane safe to take daily?

Sulforaphane is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Sulforaphane

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Sulforaphane is the most potent natural activator of Nrf2 — the master regulator of the body's antioxidant and detoxification defenses. Our research shows it reduces markers of autism spectrum disorder symptoms by 34% in a 2014 RCT (one of the most striking findings for any supplement in neuropsychiatry), has consistent evidence for cancer chemoprevention, and genuinely enhances phase II detoxification enzymes. The catch: sulforaphane is unstable and most supplements don't actually deliver meaningful amounts. Only products providing active myrosinase enzyme alongside glucoraphanin (its precursor) or stabilized sulforaphane reliably work.

WHAT IT DOES

Sulforaphane activates Nrf2 (nuclear factor erythroid 2-related factor 2) by modifying Keap1 — the protein that normally keeps Nrf2 locked in the cytoplasm. When sulforaphane modifies Keap1, Nrf2 is released, enters the nucleus, and switches on over 200 cytoprotective genes including: glutathione S-transferases (phase II detox), NAD(P)H quinone oxidoreductase (NQO1), heme oxygenase-1 (anti-inflammatory), and glutathione synthesis enzymes. This massive upregulation of cellular defenses is why sulforaphane shows benefits across such diverse conditions — it's not treating a specific disease, it's enhancing the body's fundamental protection systems.

OPTIMAL DOSAGE

Look for: Broccoli sprout extract WITH active myrosinase enzyme; or stabilized sulforaphane with quantified sulforaphane content (mg); Prostaphane, Avmacol, or BroccoMax brands
Avoid: Products listing only "broccoli extract" without sulforaphane quantification; glucoraphanin-only products without myrosinase (you need the enzyme); products using mature broccoli instead of sprouts
Minimum effective dose: 20mg sulforaphane/day
Third-party tested brands: Avmacol (most clinical data), Prostaphane (French pharmaceutical-grade), Jarrow BroccoMax

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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