What is the recommended dose of Stinging Nettle?

- **Look for:** ROOT extract for prostate (clearly labeled "root"); freeze-dried LEAF for allergies (clearly labeled "leaf"); standardized extract; 120-600mg per serving - **Avoid:** Products not s...

Is Stinging Nettle safe to take daily?

Stinging Nettle is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Stinging Nettle

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Stinging nettle has two entirely different clinical applications depending on which PART is used: ROOT extract for BPH/prostate (binds SHBG and 5-alpha reductase) and LEAF extract for allergies (anti-histamine). Our research shows the root has moderate evidence for BPH symptom improvement (a German trial found comparable improvement to finasteride in mild BPH), while the leaf freeze-dried extract reduced allergy symptoms by 58% in a crossover trial. These are pharmacologically distinct — the root contains lignans (anti-androgenic) while the leaf contains histamine-modulating compounds.

WHAT IT DOES

ROOT: Nettle root lignans (secoisolariciresinol, 3,4-divanillyltetrahydrofuran) competitively bind to SHBG, preventing SHBG from binding testosterone (increasing free testosterone). The root also inhibits 5-alpha reductase (reducing DHT) and aromatase (reducing estrogen conversion). This dual anti-androgenic + free testosterone-increasing profile makes it useful for BPH. LEAF: Contains histamine (paradoxically), quercetin, and other flavonoids that modulate mast cell degranulation and histamine release. Freeze-drying preserves these compounds. The anti-allergy mechanism may involve lectins that bind to IgE receptors, preventing mast cell activation.

OPTIMAL DOSAGE

Look for: ROOT extract for prostate (clearly labeled "root"); freeze-dried LEAF for allergies (clearly labeled "leaf"); standardized extract; 120-600mg per serving
Avoid: Products not specifying root vs leaf (completely different uses); nettle tea for therapeutic purposes (too dilute); non-freeze-dried leaf for allergies
Minimum effective dose: Root: 120mg/day. Leaf: 300mg 3x/day (freeze-dried)
Third-party tested brands: Eclectic Institute (freeze-dried leaf), NOW Foods (root extract), Nature's Way

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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