Is Squalene / Squalane safe to take daily?

Squalene / Squalane is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Squalene / Squalane

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Squalene is a triterpene produced by human sebaceous glands (skin's natural moisturizer) and found in high concentrations in shark liver oil and olive oil. Functions as: (1) skin moisturizer/emollient; (2) antioxidant (singlet oxygen quencher); (3) cholesterol synthesis intermediate; (4) vaccine adjuvant (MF59 in flu vaccines contains squalene). Amaranth seed oil is the richest plant source (8% squalene). Oral supplementation: limited data. Topical squalane (hydrogenated squalene): excellent skin penetration, non-comedogenic, oxidation-stable. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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