Is Spilanthes safe to take daily?

Spilanthes is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Spilanthes

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Spilanthes contains spilanthol — a unique N-alkylamide that causes a tingling/numbing sensation on contact with mucous membranes. Used as a natural local anesthetic for toothache (hence the name). Also an immunostimulant (activates macrophage phagocytosis). The tingling sensation is from TRPV1/TRPA1 activation followed by desensitization. Used in Ayurveda (Akarkara) for libido and stamina. Limited clinical data beyond traditional use and in vitro immune studies. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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