Spilanthes contains spilanthol — a unique N-alkylamide that causes a tingling/numbing sensation on contact with mucous membranes. Used as a natural local anesthetic for toothache (hence the name). Also an immunostimulant (activates macrophage phagocytosis). The tingling sensation is from TRPV1/TRPA1 activation followed by desensitization. Used in Ayurveda (Akarkara) for libido and stamina. Limited clinical data beyond traditional use and in vitro immune studies. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.