Crocin and safranal — antidepressant activity comparable to fluoxetine and imipramine in 6 RCTs. 30mg/day. Also improves sexual dysfunction and reduces PMS. Affron® is the branded extract. The most expensive spice in the world (,000-10,000/kg). --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.