What is the recommended dose of Rutin?

- **Look for:** Rutin or troxerutin (hydroxyethylrutoside); 500mg+ per serving; Venoruton® for CVI - **Avoid:** Extremely low doses in combination products; confusion with quercetin (related but di...

Is Rutin safe to take daily?

Rutin is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Rutin

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Rutin is quercetin with a sugar molecule (rutinose) attached. Despite being a quercetin glycoside, it has DISTINCT pharmacological effects from quercetin because it's metabolized differently — gut bacteria must cleave the sugar to release quercetin, and the intact rutin molecule has independent anti-thrombotic and vasoprotective activities. Our research shows rutin has stronger evidence for venous insufficiency and varicose veins than quercetin, while quercetin has stronger evidence for anti-inflammatory and immune effects. Rutin is used in the Wobenzym formula specifically for its capillary-strengthening effects. Found naturally in buckwheat, citrus fruits, and asparagus.

WHAT IT DOES

Rutin has dual activity: (1) Intact molecule (venous system): strengthens capillary walls by reducing endothelial permeability — inhibits MMP-2/MMP-9 (enzymes that degrade vascular basement membrane); reduces edema by sealing capillary leaks; inhibits PDI on platelets (novel anti-thrombotic without bleeding risk); (2) After gut bacterial hydrolysis → quercetin (systemic): NF-κB inhibition, COX/LOX inhibition, mast cell stabilization, antioxidant. The distinction is important: rutin's venous effects are separate from quercetin's anti-inflammatory effects.

OPTIMAL DOSAGE

Look for: Rutin or troxerutin (hydroxyethylrutoside); 500mg+ per serving; Venoruton® for CVI
Avoid: Extremely low doses in combination products; confusion with quercetin (related but different applications)
Minimum effective dose: 500mg/day rutin; 300mg/day troxerutin
Third-party tested brands: NOW Foods, Life Extension, Venoruton (Novartis)

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SAFETY PROFILE

Moderate Interactions (Monitor Closely)

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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