Is Rauwolfia safe to take daily?

Rauwolfia is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Rauwolfia

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Rauwolfia serpentina contains reserpine (the first modern antihypertensive drug) and alpha-yohimbine (rauwolscine). Alpha-yohimbine is sold as a 'stubborn fat burner' — it's an alpha-2 adrenergic antagonist that releases norepinephrine (blocks the receptor that INHIBITS fat burning in problem areas). HOWEVER: the dose window is extremely narrow. Reserpine depletes catecholamine stores causing SEVERE depression (historical use discontinued for this reason). Our assessment: HIGH RISK. Alpha-yohimbine has no clinical trials as a supplement. Reserpine contamination in crude rauwolfia products is dangerous. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

Scan a supplement containing Rauwolfia

RELATED RESEARCH

Acacia Fiber

Activated Charcoal

Agave Inulin

Agmatine SulfateReduced neuropathic pain by 46.1%

Scan Your Rauwolfia Supplement Browse all ingredients

Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

Discover More

Explore

Browse All 834 Ingredients Browse All 20 Conditions