Pyruvate

Pyruvate is a 3-carbon molecule at the intersection of glucose and fat metabolism (glycolysis produces pyruvate → enters mitochondria for TCA cycle). Supplementation at VERY high doses (22-44g/day) showed modest fat loss in early studies, but those doses are impractical and cause severe GI distress. At practical doses (5-10g/day), effects are negligible. A 2009 Cochrane review found pyruvate produced only 0.72 kg more weight loss than placebo — statistically significant but clinically meaningless. NOT recommended due to poor effect:dose ratio. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*