What is the recommended dose of Pterostilbene?

- **Look for:** Trans-pterostilbene; pTeroPure® brand; 50-150mg per serving - **Avoid:** Products not specifying trans isomer; doses >250mg/day (LDL concern amplifies); proprietary blends - **Minim...

Is Pterostilbene safe to take daily?

Pterostilbene is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Pterostilbene

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Pterostilbene is a dimethylated analog of resveratrol found in blueberries and grapes, with 4x better oral bioavailability (80% vs resveratrol's 20%). Our research shows it addresses resveratrol's biggest weakness — actually getting absorbed. A 2014 RCT found 100mg/day lowered blood pressure by 7.8 mmHg but INCREASED LDL cholesterol by 5-9%, creating a mixed cardiovascular profile. It activates SIRT1 and PPAR-α similarly to resveratrol but at achievable blood levels. The LDL increase is the primary safety concern that distinguishes it from its better-known cousin.

WHAT IT DOES

Pterostilbene's two methyl groups (vs resveratrol's hydroxyl groups) make it more lipophilic, dramatically improving absorption and half-life. It activates SIRT1 (longevity pathway), PPAR-α (lipid metabolism), and AMPK (metabolic sensor), while inhibiting NF-κB (inflammation). For blood pressure, it increases NO bioavailability and reduces vascular oxidative stress. The LDL increase mechanism is unclear — it may involve PPAR-α-mediated changes in lipoprotein metabolism. The 4x bioavailability advantage means you can achieve plasma levels with 100mg pterostilbene that would require 500mg+ resveratrol.

OPTIMAL DOSAGE

Look for: Trans-pterostilbene; pTeroPure® brand; 50-150mg per serving
Avoid: Products not specifying trans isomer; doses >250mg/day (LDL concern amplifies); proprietary blends
Minimum effective dose: 50mg/day
Third-party tested brands: Life Extension (pTeroPure), Thorne, Jarrow Formulas

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

No critical interactions identified at standard doses.

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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