Pycnogenol® is a standardized extract of French maritime pine bark (Pinus pinaster) containing procyanidins, phenolic acids, and taxifolin. Our research shows it has the broadest evidence base of any pine bark extract, with over 160 clinical trials covering cardiovascular health, skin aging, ADHD in children, endometriosis, and erectile dysfunction. A 2012 meta-analysis confirmed it reduces blood pressure by 3-5 mmHg, and a 2006 RCT found it improved ADHD symptoms by 26% in children. The procyanidin profile is similar to grape seed extract but with additional unique compounds.
Pycnogenol's oligomeric procyanidins (OPCs) work through: (1) potent endothelial nitric oxide synthase (eNOS) activation — increasing NO production for vasodilation and blood pressure reduction; (2) collagen and elastin cross-linking protection — inhibiting the enzymes (MMPs, elastase, collagenase) that degrade skin and vascular structural proteins; (3) antiplatelet activity — reducing thromboxane A2 without affecting prostacyclin (aspirin-like but milder); (4) NF-κB inhibition — broad anti-inflammatory effect; (5) modulation of catecholamine metabolism — the proposed mechanism for ADHD improvement (increased dopamine/norepinephrine availability).
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.