What is the recommended dose of Phosphatidylserine?

- **Look for:** Soy-derived or sunflower-derived PS, 100-300mg per serving; Sharp-PS brand (most clinical data); specify PS content (not just "phospholipid complex") - **Avoid:** Products listing "...

Is Phosphatidylserine safe to take daily?

Phosphatidylserine is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Phosphatidylserine

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Phosphatidylserine is a phospholipid that constitutes 15% of the brain's total phospholipid pool and is critical for cell membrane fluidity, neurotransmitter release, and cortisol regulation. Our research shows moderate evidence for cognitive decline in the elderly — the FDA even authorized a qualified health claim (rare for supplements). PS also reduces exercise-induced cortisol by 20-30%, making it popular among athletes. The original bovine brain-derived PS (BC-PS) was replaced by soy-derived PS after BSE/mad cow concerns, though the evidence was primarily generated with the bovine form.

WHAT IT DOES

PS is a structural component of neuronal cell membranes that influences: (1) membrane fluidity — determining how well receptors and ion channels function; (2) acetylcholine release — directly enhancing the primary memory neurotransmitter; (3) cortisol regulation — PS supplementation blunts HPA axis activation, reducing cortisol output during physical and psychological stress; (4) apoptosis signaling — PS normally resides on the inner membrane leaflet; its externalization signals "eat me" to macrophages. Supplemental PS replenishes depleted neuronal membranes, which deteriorate with aging and chronic stress.

OPTIMAL DOSAGE

Look for: Soy-derived or sunflower-derived PS, 100-300mg per serving; Sharp-PS brand (most clinical data); specify PS content (not just "phospholipid complex")
Avoid: Products listing "phospholipid blend" without quantifying PS; products with <50mg PS per serving; bovine brain-derived (no longer safe/available)
Minimum effective dose: 100mg/day for cognitive support; 400mg/day for cortisol blunting
Third-party tested brands: Jarrow Formulas (PS 100), NOW Foods (Sharp-PS), Doctor's Best

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

No critical interactions identified.

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

WHO SHOULD BE CAREFUL

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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