Perilla leaf extract contains rosmarinic acid and luteolin — potent mast cell stabilizers. A 2004 RCT found 50mg rosmarinic acid from perilla reduced allergic rhinitis symptoms significantly — reduced sneezing, nasal blockage, and itchy eyes by 50-70%. The mechanism: rosmarinic acid inhibits IgE-mediated mast cell degranulation AND blocks 5-LOX/COX-2 (dual anti-inflammatory). Japanese Kampo medicine uses perilla for allergies and asthma. Dose: 200-500mg/day perilla extract standardized to rosmarinic acid. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.