Extra virgin olive oil (EVOO) contains hydroxytyrosol and oleocanthal — the compound that creates the 'throat burn' sensation. Oleocanthal inhibits COX-1 and COX-2 identically to ibuprofen (same mechanism, same potency per molecule — Beauchamp 2005, Nature). PREDIMED trial (7,447 participants): EVOO supplementation (50mL/day) reduced cardiovascular events by 30%. Hydroxytyrosol is the EU's ONLY food compound with an approved health claim for cardioprotection (EC Reg 432/2012). Dose: 20mg/day hydroxytyrosol (from ~25-50mL EVOO). Hydroxytyrosol supplements are emerging. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.