NALT

NALT is the acetylated form of tyrosine marketed as 'more bioavailable.' Paradoxically, NALT is LESS effective than L-tyrosine for raising brain catecholamines because the acetyl group must be cleaved first, and the enzyme (aminoacylase) that does this is rate-limited. Only ~56% of NALT is converted to free tyrosine in the kidneys. L-tyrosine is the preferred form. NALT's advantage is higher water solubility (useful for powder supplements). Our assessment: L-tyrosine > NALT for efficacy. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*