Casein-derived bioactive peptides (alpha-s1 casein tryptic hydrolysate) that bind GABA-A receptors — producing anxiolytic effects without sedation or dependence. Lactium® (Ingredia, France) is the branded extract: 150mg/day reduced cortisol and improved stress/sleep in a 30-day RCT. The specific decapeptide YLGYLEQLLR was identified as the active sequence. Also: C12 peptide from casein inhibits ACE (angiotensin-converting enzyme) — mild antihypertensive. Safe for long-term use. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.