MCTs (C6-C12) are water-soluble enough to be absorbed directly from the intestine into the portal vein WITHOUT requiring bile acid emulsification, pancreatic lipase, or chylomicron formation. They travel directly to the liver, where they undergo rapid β-oxidation → acetyl-CoA → ketone bodies (β-hydroxybutyrate, acetoacetate). Ketones cross the blood-brain barrier via MCT1 transporter and serve as alternative fuel for neurons. In Alzheimer's, brain glucose transporters (GLUT1, GLUT3) are impaired by 25-40%, but ketone transporters remain functional — MCT-derived ketones bypass the glucose bottleneck. For weight management: MCTs have 10% fewer calories per gram than long-chain fats (8.3 vs 9.0 kcal/g) and increase thermogenesis via uncoupling protein activation.
No critical interactions identified.
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.