Mango leaf contains mangiferin — a C-glucosylxanthone with potent antioxidant, anti-diabetic, and neuroprotective activity. Zynamite® (standardized mango leaf extract, 60% mangiferin) improved cognitive performance and exercise endurance comparably to caffeine in a 2018 study — WITHOUT stimulant side effects. Mangiferin activates AMPK and inhibits α-glucosidase (blood sugar control). Also inhibits PDE2 (cognitive) and PDE3 (cardiovascular). Dose: 140-420mg/day Zynamite. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.