Is Mango Leaf Extract safe to take daily?

Mango Leaf Extract is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Mango Leaf Extract

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Mango leaf contains mangiferin — a C-glucosylxanthone with potent antioxidant, anti-diabetic, and neuroprotective activity. Zynamite® (standardized mango leaf extract, 60% mangiferin) improved cognitive performance and exercise endurance comparably to caffeine in a 2018 study — WITHOUT stimulant side effects. Mangiferin activates AMPK and inhibits α-glucosidase (blood sugar control). Also inhibits PDE2 (cognitive) and PDE3 (cardiovascular). Dose: 140-420mg/day Zynamite. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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