Licorice Root

Licorice root contains glycyrrhizin — a compound 30-50x sweeter than sugar that inhibits 11β-HSD2 (the enzyme that inactivates cortisol in the kidneys). This causes cortisol to accumulate and activate mineralocorticoid receptors → sodium retention → hypertension → hypokalemia. At normal consumption (<100mg glycyrrhizin/day, equivalent to ~50g licorice) effects are minimal. At higher doses: pseudoaldosteronism (mimics excess aldosterone). BENEFICIAL uses: anti-viral (glycyrrhizin inhibits SARS-CoV replication), anti-ulcer (mucosal protection), and adrenal support (extends cortisol half-life in adrenal insufficiency). for the safe GI form. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*