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Larch arabinogalactan: (1) Prebiotic fermentation — gut bacteria (particularly Bifidobacterium) ferment arabinogalactan to SCFAs (butyrate, propionate, acetate), promoting beneficial microbiome composition; (2) Complement activation — LA activates the complement system via the alternative pathway, enhancing opsonization and pathogen clearance; (3) Macrophage activation — LA binds to macrophage surface receptors, stimulating phagocytosis and cytokine production (IL-1, IL-6, TNF-α); (4) NK cell enhancement — increases NK cell cytotoxicity (mechanism not fully elucidated — may involve macrophage-derived cytokines that activate NK cells); (5) IgG enhancement — improves antibody response to vaccination.
No significant drug interactions identified. LA is a dietary fiber with low systemic absorption.
Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.