Soy Isoflavones

Soy isoflavones (genistein, daidzein, glycitein) are phytoestrogens with SERM-like activity. Meta-analysis: 54mg/day reduces hot flashes by 21%. Bone: 90mg/day improved lumbar spine BMD by 2% over 12 months. Breast cancer: PROTECTIVE in Asian populations (high lifetime soy intake) — but data is less clear for Western women starting soy supplementation later in life. Equol producers (30% of Westerners, 60% of Asians) show stronger responses. NOT associated with feminization or gynecomastia in men at normal intake. Key study: Messina 2010 meta-analysis of 15 studies found NO effect on testosterone in men. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*