What is the recommended dose of Inositol?

- **PCOS:** 2,000-4,000mg myo-inositol + 50-100mg D-chiro-inositol per day (40:1 ratio) - **Anxiety/panic disorder:** 12,000-18,000mg/day (myo-inositol alone) - **OCD:** 18,000mg/day - **Gestationa...

Is Inositol safe to take daily?

Inositol is rated "Use Caution" based on clinical evidence. - GI effects (nausea, bloating, diarrhea) at high doses (>12g) — most common - Insomnia (occasionally reported) - Generally very well tolerated even at gram-level doses

Does Inositol interact with any medications?

Inositol has 4 known drug interactions, including interactions with Lithium, SSRIs, Diabetes medications. Check with your doctor before combining with prescription medications.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Inositol

STRONG EVIDENCESupplementLast updated April 2026

AVELOR SUMMARY

Inositol is a carbocyclic sugar involved in insulin signaling and serotonergic neurotransmission. Our research shows strong evidence for PCOS (improving ovulation, insulin resistance, and hormonal profiles) and moderate evidence for anxiety/panic disorder at high doses. Myo-inositol is the primary therapeutic form; D-chiro-inositol is used specifically for insulin resistance. The 40:1 ratio (myo:D-chiro) mirrors physiological proportions and is the best-studied combination.

EVIDENCE GRADES

PCOS (ovulation, hormones, insulin)Strong — multiple RCTs, meta-analyses (PMID: 28535580)

A-

Panic disorder / anxietyModerate — 12-18g/day (PMID: 7726322)

OCDSome positive trials at high doses

C+

DepressionMixed results

Gestational diabetes preventionModerate — positive in at-risk populations

B-

Neural tube defect preventionAdjunct to folate in resistant cases

C+

OPTIMAL DOSAGE

PCOS: 2,000-4,000mg myo-inositol + 50-100mg D-chiro-inositol per day (40:1 ratio)
Anxiety/panic disorder: 12,000-18,000mg/day (myo-inositol alone)
OCD: 18,000mg/day
Gestational diabetes prevention: 4,000mg myo-inositol/day from first trimester
Powder form preferred at high doses (capsules impractical for 12-18g)
Well absorbed, mildly sweet taste

Scan a supplement containing Inositol

DRUG INTERACTIONS

LithiumModerate

Lithium depletes inositol; inositol supplementation may alter lithium's mood-stabilizing mechanism

SSRIsModerate

Inositol has serotonergic activity; additive effects (mostly beneficial but monitor)

Diabetes medicationsModerate

D-chiro-inositol improves insulin signaling; additive hypoglycemia risk

Carbamazepine / valproic acidMinor

May deplete inositol; supplementation may be beneficial

SAFETY PROFILE

Drug Interactions

Side Effects

GI effects (nausea, bloating, diarrhea) at high doses (>12g) — most common
Insomnia (occasionally reported)
Generally very well tolerated even at gram-level doses

Pregnancy & Lactation

Myo-inositol at 4,000mg/day studied in pregnancy for gestational diabetes prevention — appears safe with positive outcomes (PMID: 26356985). Increasingly recommended by OBs for at-risk pregnancies.

WADA Status

Not Prohibited

HOW AVELOR SCORES THIS

40:1 ratio (myo:D-chiro) is the gold standard for PCOS — products using other ratios get flagged

D-chiro-inositol alone at high doses may actually worsen ovarian function in PCOS — flag as concerning

Anxiety applications require 12-18g/day — products at 2-4g marketed for anxiety should note dose gap

Powder form preferred for high-dose applications (>4g)

Lithium users: interaction flag (mechanism-based concern)

Pregnancy: one of the few supplements with positive safety data in pregnancy (GDM prevention)

CLINICAL REFERENCES

Unfer V et al. Myo-inositol effects in women with PCOS: a meta-analysis.

PMID: 28535580

Benjamin J et al. Double-blind, placebo-controlled, crossover trial of inositol in panic disorder.

PMID: 7726322

D'Anna R et al. Myo-inositol supplementation and onset of gestational diabetes mellitus in pregnant women with family history.

PMID: 26356985

Pundir J et al. Inositol treatment of anovulation in women with PCOS.

PMID: 23314244

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

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