Hops contain 2-methyl-3-buten-2-ol (a GABA-A positive modulator formed from alpha-acids during storage) and 8-prenylnaringenin (the most potent phytoestrogen known — 50x more potent than soy isoflavones). For SLEEP: hops + valerian combination has 4+ clinical trials showing improved sleep quality. For MENOPAUSE: 8-prenylnaringenin reduced hot flashes by 60% in a 2006 trial. The sedative effect requires AGED hops (fresh hops are stimulating). Dose: 300-500mg standardized hop extract. --- *Reviewed by the Dose AI Research Team and Clinical Advisory Board* *Last updated: 2026-04-06*
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.