What is the recommended dose of Higenamine?

- **Look for:** AVOID this ingredient entirely - **Avoid:** Products containing higenamine, Nandina domestica, Aconitum extract, Nelumbo nucifera extract (lotus seed), or "demethylcoclaurine" (chem...

Is Higenamine safe to take daily?

Higenamine is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Higenamine

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Higenamine is a beta-2 adrenergic receptor agonist found in several plants (Aconitum, Nandina, Nelumbo nucifera). It's marketed as a pre-workout thermogenic ("natural DMAA replacement") but our research shows this is a DANGEROUS supplement with ZERO human clinical trials, significant cardiac stimulant effects, and it's BANNED by WADA (World Anti-Doping Agency) since 2017. Higenamine has the same mechanism as clenbuterol (beta-2 agonist) but without ANY dose-response safety data in humans. Multiple adverse event reports including cardiac arrhythmias. The supplement industry started selling it after DMAA and ephedra were banned — it's the next unsafe stimulant in the whack-a-mole game.

WHAT IT DOES

Higenamine activates beta-2 adrenergic receptors: (1) Bronchial smooth muscle relaxation (bronchodilatory — why it's in traditional Chinese medicine for asthma); (2) Lipolysis stimulation in adipocytes (via cAMP→PKA pathway — same as epinephrine); (3) Cardiac stimulation (positive inotropic and chronotropic — increases heart rate and contractile force); (4) Skeletal muscle vasodilation. The PROBLEM: beta-2 agonists have narrow therapeutic windows. Without human dose-response data, there is no way to determine a safe dose. The cardiac stimulant effects are the primary safety concern.

OPTIMAL DOSAGE

Look for: AVOID this ingredient entirely
Avoid: Products containing higenamine, Nandina domestica, Aconitum extract, Nelumbo nucifera extract (lotus seed), or "demethylcoclaurine" (chemical name for higenamine); pre-workout/fat burner blends with undisclosed stimulants
Red flags: Pre-workout products banned by military exchanges; "proprietary stimulant blends"; products marketed as "DMAA replacement"

Scan a supplement containing Higenamine

SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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