What is the recommended dose of Gamma-Oryzanol?

- **Look for:** Standardized to gamma-oryzanol content; 100-300mg per serving; rice bran extract - **Avoid:** Rice bran oil food product (insufficient gamma-oryzanol); products marketed for bodybui...

Is Gamma-Oryzanol safe to take daily?

Gamma-Oryzanol is rated "Generally Safe" based on clinical evidence. Always consult your healthcare provider before starting any supplement.

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Ingredient Research

Graded against 173,636 supplements + 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, NIH DSLD

Gamma-Oryzanol

MODERATE EVIDENCESupplementLast updated

AVELOR SUMMARY

Gamma-oryzanol is a mixture of ferulic acid esters found in rice bran oil, popular in Japan (where it's an approved pharmaceutical for hyperlipidemia and menopause) but relatively unknown in Western supplement markets. Our research shows it has moderate evidence for cholesterol reduction (LDL down 10-15% at 300mg/day) and menopausal hot flash reduction (85% of women reported improvement). However, the early 1990s claims about testosterone-boosting and bodybuilding were definitively debunked — a 1997 RCT found ZERO effect on hormones or body composition. It's primarily relevant as a gentle lipid-lowering agent and menopause support.

WHAT IT DOES

Gamma-oryzanol is a mixture of ferulate esters of sterols and triterpene alcohols. The lipid-lowering mechanism involves: (1) ferulic acid inhibiting HMG-CoA reductase (mild statin-like effect); (2) reducing intestinal cholesterol absorption by inhibiting cholesterol esterase; (3) upregulating hepatic LDL receptor expression, increasing LDL clearance. For menopause, it modulates the hypothalamic-pituitary axis — specifically reducing LH surges that trigger hot flashes — without direct estrogenic activity (not a phytoestrogen). It also has gastric mucosal protective effects via increased prostaglandin E2 synthesis.

OPTIMAL DOSAGE

Look for: Standardized to gamma-oryzanol content; 100-300mg per serving; rice bran extract
Avoid: Rice bran oil food product (insufficient gamma-oryzanol); products marketed for bodybuilding (debunked); proprietary blends
Minimum effective dose: 100mg/day
Third-party tested brands: Source Naturals, Swanson

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SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

No critical interactions identified.

Moderate Interactions (Monitor Closely)

Theoretical/Low-Risk Interactions

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Independently graded against 173,636 indexed supplements with 177 published clinical interactions, sourced from PubMed, FDA CAERS, openFDA, and NIH DSLD | Last updated:

Not medical advice. Based on published clinical research and systematic reviews.

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