Fucoidan

WHAT IT DOES

Fucoidan's biological activities: (1) Immune modulation — activates NK cells, macrophages, and dendritic cells via TLR4 and scavenger receptor binding; increases IL-12 and IFN-γ production (Th1 immune shift); (2) Anti-angiogenic — suppresses VEGF and VEGFR signaling, starving tumors of blood supply; (3) Anti-metastatic — blocks selectin-mediated adhesion of circulating tumor cells to endothelium (selectins are the "Velcro" that tumors use to stick to blood vessel walls and metastasize); (4) Anticoagulant — mimics heparin by activating antithrombin III (structure contains sulfated fucose residues similar to heparin's sulfated glucosamine); (5) Prebiotic — fermented by beneficial gut bacteria (Bifidobacterium, Lactobacillus) to SCFAs. Major caveat: oral bioavailability of large polysaccharides is poor.

OPTIMAL DOSAGE

SAFETY PROFILE

Critical Interactions (Do Not Combine Without Medical Supervision)

Moderate Interactions (Monitor Closely)