Fisetin is a flavonoid found in strawberries and is the most potent natural senolytic compound identified — clearing senescent ("zombie") cells that accumulate with aging and drive chronic inflammation. A 2018 study in Nature Medicine found fisetin extended median lifespan in aged mice by 10%. The Mayo Clinic is running active clinical trials in humans. Our research flags that bioavailability is extremely poor (oral absorption <5%), making dose form critical — and the human evidence base, while exciting, consists mainly of ongoing trials, not published results.
Senescent cells are damaged cells that stop dividing but refuse to die — they accumulate with age and pump out inflammatory cytokines (the SASP — senescence-associated secretory phenotype) that damage surrounding tissue and drive chronic inflammation, tissue deterioration, and age-related disease. Fisetin triggers apoptosis (programmed cell death) specifically in these senescent cells while leaving healthy cells unaffected. It does this by inhibiting the PI3K/AKT/mTOR survival pathway that senescent cells depend on. It also activates SIRT1, reduces NF-κB-driven inflammation, and has direct antioxidant activity.
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.