Fadogia agrestis is a Nigerian shrub that gained massive popularity after Andrew Huberman recommended it alongside tongkat ali for testosterone support. Our research reveals a concerning reality: there is exactly ONE animal study showing testosterone increase — in rats, at doses equivalent to 18-100mg/kg — and that SAME study found dose-dependent testicular toxicity (testicular cell damage) at the effective doses. There are ZERO human clinical trials. This is one of the highest-risk supplements in our database due to the combination of organ toxicity signal and complete absence of human safety data.
The proposed mechanism (from the single rat study) is that fadogia's alkaloids and saponins stimulate Leydig cells to produce more testosterone — similar to how LH works. However, the same stimulation appears to damage those cells at effective doses. It's essentially overstimulating the testosterone-producing machinery until it breaks. The alkaloids involved have not been fully characterized, the dose-response curve in humans is completely unknown, and there is no safety margin established.
Insufficient data to classify any interaction as "low-risk" — ALL interactions are unknown.
Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated:
Not medical advice. Based on published clinical research and systematic reviews.