Reviewed by the Scan Dose Research Team and Clinical Advisory Board
Beta-Glucans
STRONG EVIDENCESupplementLast updated April 2026
SCAN DOSE SUMMARY
Beta-glucans are polysaccharides found in oats, mushrooms, and yeast with strong evidence for cholesterol reduction (oat-derived) and immune modulation (mushroom/yeast-derived). Different sources have entirely different mechanisms — oat beta-glucans lower cholesterol via bile acid binding, while yeast/mushroom beta-glucans activate innate immune cells.
EVIDENCE GRADES
LDL cholesterol reduction (oat)Strong — FDA health claim approved (PMID: 21631511)
Cancer adjunct (mushroom)Preliminary — mostly Asian trials
C+
WHAT IT DOES
Beta-glucans are glucose polymers with β-1,3 and β-1,6 glycosidic linkages. Source determines function:
Oat/barley β-glucans: Soluble fiber that forms viscous gel in the GI tract, binding bile acids and reducing cholesterol reabsorption. Also slows glucose absorption.
Mushroom β-glucans (reishi, maitake, shiitake, turkey tail): Bind Dectin-1 and complement receptor 3 on macrophages and NK cells, activating innate immune surveillance.
Yeast β-glucans (Saccharomyces cerevisiae): Most potent immune activators; used in Wellmune WGP branded ingredient.
OPTIMAL DOSAGE
Cholesterol (oat): 3g/day minimum (FDA health claim threshold)
Immune support (yeast): 250-500mg/day
Immune support (mushroom): 200-500mg/day of standardized extract
Take oat beta-glucans with meals for cholesterol and glucose benefits