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Reviewed by the Scan Dose Research Team and Clinical Advisory Board

Astaxanthin

MODERATE EVIDENCESupplementLast updated April 2026

SCAN DOSE SUMMARY

Astaxanthin is a carotenoid antioxidant found in salmon, shrimp, and microalgae — 10-100x more potent than other carotenoids in singlet oxygen quenching. Our research shows moderate evidence for oxidative stress reduction, skin UV protection, and exercise recovery. Remarkably safe with virtually no drug interactions.

EVIDENCE GRADES

Oxidative stress biomarkersModerate — consistent reductions in MDA, 8-OHdG
B
Skin UV protectionModerate — reduced sunburn, improved elasticity
B-
Exercise performance/recoveryModerate — reduced exercise-induced oxidative damage
B-
Cardiovascular markersPreliminary — improved lipid profiles in some trials
C+
Eye health (asthenopia)Limited but positive
C+

WHAT IT DOES

Astaxanthin is a xanthophyll carotenoid responsible for the red-pink color of salmon, trout, shrimp, and flamingos. Unlike beta-carotene and lycopene, astaxanthin spans the entire cell membrane (both inner and outer leaflets), providing antioxidant protection across the full lipid bilayer. It quenches singlet oxygen 6,000x more effectively than vitamin C and 550x more than vitamin E (PMID: 21457902).

Most supplemental astaxanthin is derived from Haematococcus pluvialis microalgae. Synthetic astaxanthin exists but lacks the esterified form found in nature.

OPTIMAL DOSAGE

  • General antioxidant: 4-12mg/day
  • Skin protection: 4-6mg/day for 6-8 weeks before sun exposure
  • Exercise recovery: 12mg/day
  • Take with fat — astaxanthin is fat-soluble; absorption increases 2-3x with dietary fat
Scan a supplement containing Astaxanthin

DRUG INTERACTIONS

Blood pressure medicationsMinor

Astaxanthin may mildly lower BP; additive effect

ImmunosuppressantsMinor

Carotenoids may modulate immune function; theoretical

Hormone-sensitive conditionsMinor

Astaxanthin inhibits 5-alpha reductase in vitro; clinical significance unclear

SAFETY PROFILE

Drug Interactions

Side Effects

  • Virtually no adverse effects reported at standard doses (4-40mg/day)
  • May turn skin slightly orange at very high doses (harmless)
  • Mild GI effects at >40mg/day

Pregnancy & Lactation

  • Limited data. Dietary astaxanthin from seafood is safe. Supplemental doses not studied.

WADA Status

Not Prohibited

WHO SHOULD BE CAREFUL

HOW SCAN DOSE SCORES THIS

Natural (Haematococcus pluvialis) scores higher than synthetic
Products declaring source organism score better
4-12mg range is well-supported; >20mg lacks additional evidence
Fat-based delivery (softgels, oil) preferred over dry capsules

CLINICAL REFERENCES

1.

Fassett RG, Coombes JS. Astaxanthin: a potential therapeutic agent in cardiovascular disease.

PMID: 21457902

2.

Davinelli S et al. Astaxanthin in skin health, repair, and disease: a comprehensive review.

PMID: 30805611

3.

Tominaga K et al. Protective effects of astaxanthin on skin deterioration.

PMID: 25232708

4.

Park JS et al. Astaxanthin decreased oxidative stress and inflammation in overweight subjects.

PMID: 21207519

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Reviewed by the Scan Dose Research Team and Clinical Advisory Board | Last updated: April 2026

Not medical advice. Based on published clinical research and systematic reviews.

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